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LYRICA® (pregabalin) What is the therapeutic dose of LYRICA® in the management of neuropathic pain?

What is the therapeutic dose of LYRICA® in the management of neuropathic pain?

The dose range is 75 to 300 mg twice daily.

Careful dose titration to the highest tolerable dose is the most appropriate approach in clinical practice.

Treatment should be initiated at a dose of 75 mg BD.

Based on individual patient response and tolerability, the dosage may be increased to
150 mg BD after 3 to 7 days, and if needed, to a maximum dose of 300 mg BD after an additional 7-days.

Dosage modification is required in patients with renal impairment (see table below).

Creatinine Clearance
(CLcr)
(mL/min)
Total Pregabalin Daily dose*Dose Regimen
Starting dose
(mg/day)
Maximum dose
(mg/day)
> 60150600Two divided doses
30 - 6075300Single daily dose or two divided doses
15 - 3025-50150Single daily dose or two divided doses
<152575Single daily dose
Supplementary dosage following haemodialysis (mg)
 25100Single dose+

*Total daily (mg/day) should be divided as indicated by dose regimen to provide mg/dose
+Supplementary dose is a single additional dose

Adapted from the LYRICA Product Information

LYRICA may be taken with or without food.

 

For additional information, please search for response documents on the HOME page

 

References:

  1. LYRICA® (pregabalin) Product Information. Pfizer Australia Pty Ltd.
  2. Freynhagen R, et al. Pain Pract. 2015; 15(1):47-57.

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