Can RELPAX® be used in combination with antidepressants?
Co-administration of serotonin (5-HT) agonists, including RELPAX, with drugs having serotonergic activity, such as serotonin noradrenaline reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs), may increase the risk of serotonin syndrome.
If concomitant treatment with RELPAX and a serotonergic active drug is clinically warranted, caution is advised. Careful observation of the patient is warranted particularly during treatment initiation or dose increase of either agent.
Concomitant use of the herbal remedy St John’s Wort (Hypericum perforatum) in patients receiving triptans should be avoided since there is a possibility of serotonergic potentiation.
Tips and Tricks
Contact Pfizer Medical Information
Monday to Friday 9am – 5pm EST