What is the maximum dose of RELPAX® that may be taken to treat a migraine?
First migraine attack treated with RELPAX.
The recommended initial dose is 40 mg, taken as early as possible after the onset of a migraine headache.
If the initial dose is ineffective, controlled clinical trials have not shown a benefit of a second dose to treat the same attack.
However, if the headache returns following initial improvement, there is evidence to suggest that a repeat 40 mg dose may be beneficial. If a second dose is required, it should not be taken within 2 hours of the initial dose.
Subsequent migraine attacks.
If the 40 mg dose is tolerated but ineffective, a maximum single dose of 80 mg may be taken to treat a subsequent migraine. A second dose of 80 mg may be taken 2 hours after the first dose if required.
The maximum single dose of RELPAX is 80 mg. The maximum daily dose should not exceed 160 mg.
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