What happens if the patient sneezes or has a runny nose?
Synarel is rapidly absorbed into the blood stream through the nasal mucosa. Nafarelin reaches Tmax in 26 minutes (range 5 to 60 minutes) and has a bioavailability of 2.8%.
How often should the Synarel® bottle be primed?
Only once, before the bottle is used for the first time. After spraying a fine mist, the bottle will not need priming again. Priming more often will result in the bottle lasting less than 60 sprays (doses).
How many doses or days will a bottle of Synarel® last?
There are a maximum of 60 sprays in one bottle.
- 1 spray morning and night = 30 days (60 sprays)
- 2 sprays morning and night = 15 days (60 sprays)
In addition to this, there is also enough to prime the bottle once.
What happens if a dose of Synarel® is missed?
If it is almost time for the next dose, skip the missed dose and take the next dose when required. Otherwise, the patient should take it as soon as they remember and then go back to taking it as they would normally. If one or more doses have been missed, a pregnancy test should subsequently be performed before treatment is to continue. Patients should not take a double dose to make up for their missed dose.
How should Synarel® be stored?
Keep Synarel in an upright position in a cool dry place where the temperature stays at 25°C and away from light. Always replace the safety clip and the dust cover; store in an upright position. Do not refrigerate or freeze.
Can the Synarel® bottle be re-used for subsequent cycles?
Do not use the spray bottle beyond 30 days if using 2 sprays per day, or beyond 15 days if using 4 sprays per day. At the end of the recommended 15 or 30 days, a small amount of liquid will be left in the bottle. Do not try to use the leftover amount as a lower dose may be administered which may interfere with the effectiveness of treatment.
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