NEOSPORIN® GU IRRIGANT STERILE Adverse Reactions (neomycin sulfate, polymyxin B sulfate)

ADVERSE REACTIONS

Neomycin occasionally causes skin sensitization when applied topically; however, topical application to mucus membranes rarely results in local or systemic hypersensitivity reactions. Irritation of the urinary bladder mucosa has been reported.

Signs of ototoxicity and nephrotoxicity have been reported following parenteral use of these drugs and following the oral and topical use of neomycin (see WARNINGS).

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